| Datum | Zeit | Heim | Gast | Ergebnis |
| 03.10.2021 | 16:00 | HSV Weimar | HSV Apolda 1990 II | 31 : 27 |
| 16.10.2021 | 17:15 | SG Suhl/Goldlauter II | HSV Apolda 1990 II | |
| 23.10.2021 | 19:30 | HSV Apolda 1990 II | SG Handball Ilmenau | |
| 27.11.2021 | 15:00 | HSV Apolda 1990 II | TSV Motor Gispersleben | |
| 04.12.2021 | 17:00 | HSV Sömmerda 05 | HSV Apolda 1990 II | |
| 08.01.2022 | 17:00 | HSV Apolda 1990 II | SG Suhl/Goldlauter II | |
| 15.01.2022 | 19:00 | SG Handball Ilmenau | HSV Apolda 1990 II | |
|
29.01.2022 |
19:30 | HSV Apolda 1990 II | HSV Weimar | |
|
05.02.2022 |
17:30 | TSV Motor Gispersleben | HSV Apolda 1990 II | |
|
26.02.2022 |
17:00 | HSV Apolda 1990 II | HSV Sömmerda 05 |